Adrenergic mechanisms coordinating circulatory and excretory functions by meditation of renin secretion

Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water. On the basis of his findings the author formulates his hypothesis that in extreme haemodynamic shifts, caused by changes in vascular tone, the renin-angiotensin system is the intrarenal mediator of natriuretic reaction, ensuring the coordination of circulatory and excretory functions in the overall regulation of water and electrolyte balance by modification of water and electrolyte excretion.