Chromomycosis. Successful treatment with 5-fluorocytosine

A case of chromomycosis, caused by Fonsecaea pedrosoi, was treated with 5-fluorocytosine. After 18 weeks of treatment the initial lesions had largely resolved, and no evidence of active disease was observed clinically, histologically or from fungal cultures of the biopsy material. Further resolution of the remaining hypertrophic scar was achieved by intralesional injections of triamcinolone acetonide. Minimal side-effects were encountered during the therapy, and no recurrence during an 18-month follow-up period was observed. The results of this study indicate that 5-fluorocytosine is an effective and relatively safe mode of therapy in chromomycosis.