Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predictability of warfarin dose requirements: theoretical considerations.

W T Sawyer

    Journal of Pharmaceutical Sciences
    |April 1, 1979
    PubMed
    Summary

    Computer models predict warfarin maintenance doses. This study found a significant statistical relationship between initial patient responses to a loading dose and projected long-term warfarin needs.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan.

    Journal of clinical pharmacology·2001
    Same author

    Evaluation of outcomes in converting from intravenous ondansetron to oral granisetron: an observational study.

    The Annals of pharmacotherapy·2001
    Same author

    Perception of chemotherapy side effects cancer versus noncancer patients.

    Cancer practice·1999
    Same author

    Quality of life in patients surviving at least 12 months following high dose chemotherapy with autologous bone marrow support.

    Psycho-oncology·1999
    Same author

    Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1998
    Same author

    Clinical and economic impact of replacing divalproex sodium with valproic acid.

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·1997

    Area of Science:

    • Pharmacology
    • Pharmacometrics
    • Clinical Pharmacy

    Background:

    • Warfarin dosing requires careful management to ensure therapeutic efficacy and minimize bleeding risks.
    • Predicting precise maintenance warfarin doses remains a challenge in clinical practice.

    Purpose of the Study:

    • To evaluate the theoretical basis for predicting warfarin maintenance dose requirements.
    • To assess the correlation between initial patient responses and long-term dosing needs.

    Main Methods:

    • Utilized computer-generated hypothetical patient data.
    • Simulated patient responses to a 10-mg/day warfarin loading dose regimen.
    • Performed statistical analysis to correlate responses with projected maintenance doses.

    Main Results:

    • A significant statistical relationship was identified between patient responses to the loading dose and predicted maintenance requirements.
    • The theoretical predictability of warfarin maintenance dose requirements was supported by the findings.

    Conclusions:

    • Initial patient responses to a warfarin loading dose can theoretically predict maintenance dose requirements.
    • This predictive model offers potential for optimizing warfarin therapy and improving patient outcomes.

    Related Experiment Videos