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Related Experiment Videos

Clinical experience with dextro-alprenolol.

J K Vohra, P L Thompson, J G Sloman

    British Medical Journal
    |March 28, 1970
    PubMed
    Summary
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    Dextro-alprenolol showed limited effectiveness for treating arrhythmias after acute myocardial infarction. The drug caused significant hypotension, outweighing any minor benefits for ventricular ectopic beats.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Arrhythmias are common complications of acute myocardial infarction.
    • Beta-blockers are frequently used in managing cardiac arrhythmias.

    Purpose of the Study:

    • To evaluate the efficacy and safety of dextro-alprenolol in patients with arrhythmias post-myocardial infarction.

    Main Methods:

    • Clinical observation of nine patients treated with dextro-alprenolol.
    • Assessment of antiarrhythmic effects and adverse events.

    Main Results:

    • Dextro-alprenolol was largely ineffective for supraventricular arrhythmias.
    • Marginal control of ventricular ectopic beats was observed.
    • A significant hypotensive effect and risk of infarction were noted.

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    Conclusions:

    • Dextro-alprenolol is not recommended for treating arrhythmias associated with acute myocardial infarction due to ineffectiveness and adverse effects.
    • The hypotensive risk outweighs potential benefits in managing post-infarction arrhythmias.