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Related Experiment Videos

Bronchodilator effects on gastric acid secretion.

L J Foster, W L Trudeau, A L Goldman

    JAMA
    |June 15, 1979
    PubMed
    Summary
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    Aminophylline, a bronchodilator, significantly increases gastric acid secretion in COPD patients. Caution is advised for those with peptic ulcers, recommending beta agonists and antacids if aminophylline is necessary.

    Area of Science:

    • Pulmonology
    • Gastroenterology
    • Pharmacology

    Background:

    • Chronic Obstructive Pulmonary Disease (COPD) management often involves bronchodilators.
    • The gastrointestinal effects of these medications, particularly on acid secretion, require investigation.

    Purpose of the Study:

    • To evaluate the impact of aminophylline and adrenergic bronchodilators on gastric acid secretion and gastrin release in COPD patients.
    • To provide guidance on bronchodilator selection for COPD patients with a history of peptic ulcer disease.

    Main Methods:

    • Nine COPD patients were administered oral and intravenous aminophylline, alongside inhaled and oral adrenergic bronchodilators.
    • Basal acid output and serum gastrin levels were measured before and after drug administration.

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    Main Results:

    • Oral and intravenous aminophylline significantly increased basal gastric acid output.
    • Inhaled epinephrine hydrochloride showed a borderline significant increase in basal acid output.
    • No significant changes in serum gastrin levels were observed for any bronchodilator.

    Conclusions:

    • Aminophylline significantly elevates gastric acid secretion in COPD patients.
    • Bronchodilator therapy in patients with peptic ulcer disease should prioritize beta agonists.
    • If aminophylline is essential, concurrent use of antacids is recommended to mitigate gastric acid effects.