Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human lymphocyte-tumor cell interaction. A scanning electron microscopy study.

D J Hurley, B A Waisbren, R M Guttman

    JAMA
    |June 15, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of injectable trace minerals (Se, Zn, Cu, and Mn) administration on the immune response elicited by primary intranasal modified-live virus vaccination in dairy calves.

    Veterinary research communications·2025
    Same author

    Circulating T cell subpopulations in dairy calves infected with Bovine viral diarrhea virus 2 and Bovine herpes virus 1 following modified-live virus booster vaccination: Effects of the administration route and trace mineral supplementation.

    Veterinary immunology and immunopathology·2025
    Same author

    Impacts of feeding a Saccharomyces cerevisiae fermentation product on productive performance, and metabolic and immunological responses during a feed-restriction challenge of mid-lactation dairy cows.

    Journal of dairy science·2022
    Same author

    Changes in serum testosterone and anti-Müllerian hormone concentration in bulls undergoing scrotal insulation.

    Domestic animal endocrinology·2021
    Same author

    Sperm-bound antisperm antibodies are associated with poor cryosurvival of stallion spermatozoa.

    Theriogenology·2021
    Same author

    Optimization of cryopreservation protocols for cooled-transported stallion semen.

    Animal reproduction science·2020
    Same journal

    Deaths Caused by Law Enforcement in the US.

    JAMA·2026
    Same journal

    Hepatitis B.

    JAMA·2026
    Same journal

    Lung Transplant for Refractory Lung-Limited Stage IV Non-Small Cell Lung Cancer.

    JAMA·2026
    Same journal

    AI vs Poetry in Medicine.

    JAMA·2026
    Same journal

    Rates of Precipitated Withdrawal in a Trial of ED-Initiated Buprenorphine for Opioid Use Disorder-Reply.

    JAMA·2026
    Same journal

    New Lungs for Lung Cancer-Perils and Promises.

    JAMA·2026
    See all related articles

    Autologous lymphocytes from breast cancer patients can destroy tumor cells, a process observed via scanning electron microscopy. This interaction involves lymphocytes losing microvilli upon cancer cell destruction.

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Background:

    • Investigating the interaction between cancer cells and immune cells is crucial for understanding tumor progression and developing immunotherapies.
    • This study focuses on the cellular mechanisms of anti-tumor immunity in breast cancer.

    Observation:

    • Scanning electron microscopy was used to visualize the dynamic interactions between metastatic adenocarcinoma cells and autologous lymphocytes.
    • Lymphocytes were observed to initially surround the malignant cells before initiating destruction.

    Findings:

    • Autologous lymphocytes effectively destroyed breast cancer cells, a phenomenon not observed with heterologous lymphocytes.
    • A key finding was the loss of microvilli on lymphocytes that were in direct contact with and destroying tumor cells.

    Related Experiment Videos

  • Evidence of cytoplasmic bridging between lymphocytes and tumor cells suggests direct cell-to-cell communication during the immune response.

    • Implications:

    • These findings highlight the potential of autologous lymphocytes in cancer immunotherapy for adenocarcinoma.
    • Understanding the morphological changes in lymphocytes during tumor cell killing can inform the development of more effective cancer treatments.
    • The observed cytoplasmic bridging may represent a novel mechanism of immune cell-mediated tumor destruction.