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Emergency management of acute phencyclidine intoxication
JACEP
|February 1, 1979
Summary
Phencyclidine (PCP) is a potent dissociative anesthetic abused as a street drug. Treatment protocols address drug therapy and supportive measures for its three dose-related intoxication stages.
Area of Science:
- Pharmacology
- Toxicology
- Emergency Medicine
Background:
- Phencyclidine (PCP) is a potent sympathomimetic and hallucinogenic dissociative anesthetic.
- As an abused street drug, it is typically smoked, allowing users to titrate their dose.
Observation:
- Clinical signs of PCP intoxication manifest in three dose-related stages.
- Signs may fluctuate between these stages, presenting a dynamic clinical picture.
Findings:
- Treatment protocols are tailored to each stage of PCP intoxication.
- Management includes specific drug therapies and comprehensive clinical and psychological supportive measures.
Implications:
- Understanding the staged progression and fluctuating nature of PCP intoxication is crucial for effective clinical management.
- Standardized treatment protocols aid in addressing the complex pharmacological and psychological effects of phencyclidine abuse.