Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mixed-function oxidation in tumors.

H D Brown, S K Chattopadhyay, S N Pennington

    British Journal of Cancer
    |March 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals.

    The Journal of neuroscience : the official journal of the Society for Neuroscience·2013
    Same author

    Influence of mineral levels upon carotene and ascorbic acid contents of Swiss chard grown in the greenhouse.

    Food research·2010
    Same author

    Decisions about prenatal testing for chromosomal disorders: perceptions of a diverse group of pregnant women.

    Journal of women's health & gender-based medicine·2000
    Same author

    Perceptual and memory biases for health-related information in hypochondriacal individuals.

    Journal of psychosomatic research·1999
    Same author

    Organizational strategies mediate nonverbal memory impairment in obsessive-compulsive disorder.

    Biological psychiatry·1999
    Same author

    Aging and the scope of visual attention.

    Gerontology·1999
    Same journal

    Efficacy and safety of a novel oral anti-vasculogenic mimicry agent, CVM-1118, in advanced well-differentiated neuroendocrine tumors: a Phase IIa trial.

    British journal of cancer·2026
    Same journal

    Altretamine induces ferroptosis in small cell lung cancer by promoting epigenetic silencing and lysosomal degradation of GPX4.

    British journal of cancer·2026
    Same journal

    Revisiting retinoic acid in AML therapy: mechanisms of action and rational combination strategies.

    British journal of cancer·2026
    Same journal

    De novo cancer-related mortality after solid organ transplantation in England: the EpCOT study.

    British journal of cancer·2026
    Same journal

    Planetary Health Diet Index and breast cancer risk.

    British journal of cancer·2026
    Same journal

    Can national lung cancer screening programs be implemented without exacerbating social disparities?

    British journal of cancer·2026
    See all related articles

    Liver microsomes exhibit altered enzyme activity in tumor-bearing and irradiated rats. Key hydroxylating enzymes like cytochrome P-450 and benzopyrene hydroxylase show significant changes, impacting metabolic pathways.

    Area of Science:

    • Biochemistry
    • Enzymology
    • Toxicology

    Background:

    • Liver microsomes contain hydroxylating enzymes linked to electron transport.
    • Enzyme activity was studied in normal, tumor-bearing, and irradiated rat livers, including Morris hepatoma 7777 and induced breast tumors.

    Purpose of the Study:

    • To investigate the activity of specific liver microsomal enzymes in various physiological and pathological conditions.
    • To compare enzyme profiles in normal versus tumor-bearing and irradiated rat livers.

    Main Methods:

    • Assessed activity of NADPH oxidase, NADP-ferricyanide reductase, NADP-cytochrome c reductase, benzopyrene hydroxylase, cytochrome P-450, and cytochrome b(5).
    • Examined enzyme distribution in normal, lactating, tumor-bearing, and whole-body irradiated Wistar and Buffalo rats.

    Related Experiment Videos

    Main Results:

    • Tumor-bearing rats showed altered NADPH oxidase, NADP-ferricyanide reductase, and benzopyrene hydroxylase activity compared to normal rats.
    • Cytochrome P-450 and cytochrome b(5) levels were decreased in tumor-bearing animals.
    • Irradiated rats exhibited increased cytochrome P-450 and NADPH oxidase, with decreased ferricyanide reductase activity.

    Conclusions:

    • Liver microsomal enzyme activity, particularly hydroxylating enzymes, is significantly affected by tumor presence and whole-body irradiation.
    • These alterations suggest a disruption of normal metabolic pathways in diseased or stressed liver states.
    • Enzyme profiling provides insights into the biochemical adaptations and consequences of tumorigenesis and radiation exposure.