Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Biochemistry·2001

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

The Journal of biological chemistry·2001

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Biochemistry·2000

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Biochemistry·2000

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Archives of biochemistry and biophysics·1999

Analysis of the Atypical Temperature Dependence and Conformational Changes During Turnover of a Lactobacillus Chlorogenic Acid Esterase.

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Conformational and Functional Divergence of RnpA Protein Subfamilies in Bacterial Ribonucleoprotein RNase P.

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Hyperfusogenic Mutations Destabilize the Postfusion Six-Helix Bundle of the Measles Virus Fusion Glycoprotein.

Biochemistry·2026

Membrane Models and the Pursuit of Coherence.

Biochemistry·2026

Combinatorial Residue Recognition in SsTx-4 Inhibition of the Kir4.1/5.1 Channel.

Biochemistry·2026

Biochemical Characterization of ABHD14A, an Outlying Member of the Metabolic Serine Hydrolase Family.

Biochemistry·2026

β-hydroxybutyrate regulates microglia M1/M2 polarization and phagocytosis through the JAK1/STAT1 pathway to reduce neuroinflammation and exert anti-epileptic effects.

Naunyn-Schmiedeberg's archives of pharmacology·2026

MRI Characteristics Distinguishing Tuberculous Arthritis from Rheumatoid Arthritis: A Comparative Study.

European journal of rheumatology·2026

Bacteria-related signals in brain metastases: evidence boundaries, tumor-microenvironment remodeling, and translational prospects.

Frontiers in cell and developmental biology·2026

Heteroresistance in Mycobacterium tuberculosis: from molecular mechanisms and advanced detection to clinical implications.

Frontiers in cellular and infection microbiology·2026

Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice.

Nature microbiology·2026

Acute myeloid leukemia with 4q12 rearrangements involving CHIC2: "pitfalls" in fluorescence in situ hybridization diagnosis of PDGFRA rearrangements.

American journal of clinical pathology·2026

Related Experiment Videos

Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei

Related Concept Videos

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.

Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

The crystal structure of N(10)-formyltetrahydrofolate synthetase from Moorella thermoacetica.

Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.

Analysis of the Atypical Temperature Dependence and Conformational Changes During Turnover of a Lactobacillus Chlorogenic Acid Esterase.

Conformational and Functional Divergence of RnpA Protein Subfamilies in Bacterial Ribonucleoprotein RNase P.

Hyperfusogenic Mutations Destabilize the Postfusion Six-Helix Bundle of the Measles Virus Fusion Glycoprotein.

Membrane Models and the Pursuit of Coherence.

Combinatorial Residue Recognition in SsTx-4 Inhibition of the Kir4.1/5.1 Channel.

Biochemical Characterization of ABHD14A, an Outlying Member of the Metabolic Serine Hydrolase Family.

β-hydroxybutyrate regulates microglia M1/M2 polarization and phagocytosis through the JAK1/STAT1 pathway to reduce neuroinflammation and exert anti-epileptic effects.

MRI Characteristics Distinguishing Tuberculous Arthritis from Rheumatoid Arthritis: A Comparative Study.

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Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice.

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Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei

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