TPNH-dependent binding of amethopterin by dihydrofolate reductase from Lactobacillus casei

Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.

Advances in enzyme regulation·1997

Minor groove hydration of DNA in aqueous solution: sequence-dependent next neighbor effect of the hydration lifetimes in d(TTAA)2 segments measured by NMR spectroscopy.

Nucleic acids research·1996

Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.

Cancer research·1995

Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells.

Oncology research·1995

Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates.

Trends in biotechnology·1994

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

Advances in enzyme regulation·1994

Targeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

Archives of biochemistry and biophysics·2026

HUWE1-mediated ubiquitination and degradation of TTC4 aggravates allergic rhinitis via inhibiting PINK1/parkin-dependent mitophagy and promoting FKBP5/NF-κB-induced Treg/Th17 imbalance: HUWE1-mediated TTC4 ubiquitination and degradation aggravates AR.

Archives of biochemistry and biophysics·2026

IGF2BP2 stabilizes SLC39A14 mRNA via m6A modification to promote ferroptosis in cerebral ischemia-reperfusion injury.

Archives of biochemistry and biophysics·2026

Comparative structural and functional attributes of Growth-Related Oncogene γ chemokine protein orthologs.

Archives of biochemistry and biophysics·2026

Renal tubular injury and inflammation in patients with methylmalonic and propionic acidemias: the role of β2-microglobulin.

Archives of biochemistry and biophysics·2026

SMPDM3B-loaded extracellular vesicles from tumor-associated macrophages drive ovarian cancer chemoresistance by inhibiting the cGAS/STING pathway.

Archives of biochemistry and biophysics·2026

Is in-vitro fertilization a risk factor for perinatal morbidity in late term pregnancies beyond 41 weeks of gestation? A comparative retrospective study.

Journal of gynecology obstetrics and human reproduction·2026

Improving follow-up utilizing Plan-Do-Study-Act cycles and a texting intervention for patients with pregnancy of unknown location.

Healthcare (Amsterdam, Netherlands)·2026

Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions-A Comprehensive Literature Review.

Andrology·2026

Meiotic Origins of Non-Mosaic Klinefelter Syndrome (47, XXY): Mechanisms, Dimorphism, and Emerging Genetic Susceptibility.

Andrology·2026

When an Intrauterine Pregnancy Is Not Reassuring: Spontaneous Heterotopic Pregnancy With Tubal Rupture.

Journal of medical cases·2026

The β-hCG-TNF-α-T cell axis in threatened abortion: unraveling the pathogenic cascade from aberrant glycosylation to inflammatory demise.

Frontiers in immunology·2026

Related Experiment Videos

TPNH-dependent binding of amethopterin by dihydrofolate reductase from Lactobacillus casei

Related Concept Videos

Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates.

Minor groove hydration of DNA in aqueous solution: sequence-dependent next neighbor effect of the hydration lifetimes in d(TTAA)2 segments measured by NMR spectroscopy.

Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.

Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells.

Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates.

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

Targeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

HUWE1-mediated ubiquitination and degradation of TTC4 aggravates allergic rhinitis via inhibiting PINK1/parkin-dependent mitophagy and promoting FKBP5/NF-κB-induced Treg/Th17 imbalance: HUWE1-mediated TTC4 ubiquitination and degradation aggravates AR.

IGF2BP2 stabilizes SLC39A14 mRNA via m6A modification to promote ferroptosis in cerebral ischemia-reperfusion injury.

Comparative structural and functional attributes of Growth-Related Oncogene γ chemokine protein orthologs.

Renal tubular injury and inflammation in patients with methylmalonic and propionic acidemias: the role of β2-microglobulin.

SMPDM3B-loaded extracellular vesicles from tumor-associated macrophages drive ovarian cancer chemoresistance by inhibiting the cGAS/STING pathway.

Is in-vitro fertilization a risk factor for perinatal morbidity in late term pregnancies beyond 41 weeks of gestation? A comparative retrospective study.

Improving follow-up utilizing Plan-Do-Study-Act cycles and a texting intervention for patients with pregnancy of unknown location.

Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions-A Comprehensive Literature Review.

Meiotic Origins of Non-Mosaic Klinefelter Syndrome (47, XXY): Mechanisms, Dimorphism, and Emerging Genetic Susceptibility.

When an Intrauterine Pregnancy Is Not Reassuring: Spontaneous Heterotopic Pregnancy With Tubal Rupture.

The β-hCG-TNF-α-T cell axis in threatened abortion: unraveling the pathogenic cascade from aberrant glycosylation to inflammatory demise.

Related Experiment Videos

TPNH-dependent binding of amethopterin by dihydrofolate reductase from Lactobacillus casei

Related Concept Videos

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