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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 27, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 5, 2010

Cloprednol therapy in steroid-dependent asthma.

G G Shapiro, D S Tattoni, V C Kelley

    Pediatrics
    |May 1, 1979
    PubMed
    Summary

    Cloprednol, a new oral corticosteroid, improved asthma symptoms in children and adolescents. This steroid therapy also enhanced adrenal function without significant adverse effects on growth or pulmonary function.

    Area of Science:

    • Pediatric Pulmonology
    • Endocrinology
    • Pharmacology

    Background:

    • Asthma management in children often requires long-term oral corticosteroid therapy.
    • Prednisone is a common treatment but can have significant side effects.
    • Investigating novel corticosteroids with improved safety profiles is crucial.

    Observation:

    • Seventeen steroid-dependent pediatric patients were switched from prednisone to cloprednol for one year.
    • Cloprednol is an oral corticosteroid with a short half-life.
    • The study assessed symptom improvement, growth, bone age, pulmonary function, and adrenal function.

    Findings:

    • Patients showed statistically significant symptom improvement on cloprednol.
    • No remarkable changes were observed in growth trends, bone age, or chest roentgenograms.

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    Published on: April 6, 2017

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    Last Updated: Jun 27, 2026

    Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
    14:39

    Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

    Published on: November 5, 2010

    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
    07:28

    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

    Published on: April 6, 2017

  • Pulmonary function remained stable during the study.
  • Fasting morning cortisol levels and response to metyrapone and ACTH challenge significantly improved.

    • Implications:

    • Cloprednol demonstrates promise as an effective oral corticosteroid for pediatric asthma.
    • It may offer a better safety profile compared to traditional corticosteroids like prednisone.
    • Further research is warranted to confirm its long-term efficacy and safety in managing steroid-dependent pediatric asthma.