Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin secretion in malignant hyperpyrexia.

M A Denborough, G L Warne, R F Moulds

    British Medical Journal
    |August 24, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term outcome of disorders of sex development.

    Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2008
    Same author

    Living with congenital adrenal hyperplasia in Vietnam: a survey of parents.

    Journal of pediatric endocrinology & metabolism : JPEM·2006
    Same author

    Quality of life and gender role behavior in disorders of sexual differentiation in India.

    Journal of pediatric endocrinology & metabolism : JPEM·2006
    Same author

    Health related quality of life and psychological outcome in patients treated for craniopharyngioma in childhood.

    Journal of pediatric endocrinology & metabolism : JPEM·2006
    Same author

    Fasting ghrelin levels are not elevated in children with hypothalamic obesity.

    The Journal of clinical endocrinology and metabolism·2005
    Same author

    24-hour ambulatory blood pressure profile in patients with congenital adrenal hyperplasia--a preliminary report.

    Journal of pediatric endocrinology & metabolism : JPEM·2004
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Patients susceptible to malignant hyperpyrexia show an increased insulin response to glucose. This suggests a potential shared membrane defect in pancreatic beta cells and muscle cells.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Endocrinology

    Background:

    • Malignant hyperpyrexia (MH) is a pharmacogenetic disorder of skeletal muscle.
    • Patients with MH exhibit an exaggerated response to certain anesthetic agents.
    • An abnormal calcium release mechanism in muscle cells is implicated in MH.

    Purpose of the Study:

    • To investigate a potential link between malignant hyperpyrexia and pancreatic beta-cell function.
    • To explore the hypothesis that a common membrane abnormality underlies both conditions.

    Main Methods:

    • Observational study comparing glucose-induced insulin response in susceptible individuals.
    • Analysis of insulin secretion patterns following glucose challenge.
    • Comparative assessment of cellular membrane characteristics (inferred).

    Related Experiment Videos

    Main Results:

    • Individuals susceptible to malignant hyperpyrexia demonstrated an elevated insulin secretion in response to glucose.
    • This heightened insulin response suggests altered pancreatic beta-cell function.

    Conclusions:

    • The findings support the hypothesis of a shared membrane abnormality in malignant hyperpyrexia.
    • This abnormality may affect both skeletal muscle and pancreatic beta cells.
    • Further research is warranted to elucidate the specific molecular mechanisms involved.