Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methyldopa liver damage.

P J Toghill, P G Smith, P Benton

    British Medical Journal
    |August 31, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Workshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV.

    Vaccine: X·2025
    Same author

    Meeting Report: WHO Workshop on modelling global mortality and aetiology estimates of enteric pathogens in children under five. Cape Town, 28-29th November 2018.

    Vaccine·2020
    Same author

    Pre-vaccination screening strategies for the use of the CYD-TDV dengue vaccine: A meeting report.

    Vaccine·2019
    Same author

    Correlation of the <i>in vitro</i> biotransformation of H3B-6527 in dog and human hepatocytes with the <i>in vivo</i> metabolic profile of <sup>14</sup>C-H3B-6527 in a dog mass balance study.

    Xenobiotica; the fate of foreign compounds in biological systems·2019
    Same author

    Childhood pneumonia and crowding, bed-sharing and nutrition: a case-control study from The Gambia.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2016
    Same author

    Post-hoc comparison of vitamin D status at three timepoints during pregnancy demonstrates lower risk of preterm birth with higher vitamin D closer to delivery.

    The Journal of steroid biochemistry and molecular biology·2014
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Methyldopa can cause liver damage, including hepatitic syndromes and jaundice, in patients. Some individuals experienced recurring liver issues upon re-administration of this medication.

    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Drug-Induced Liver Injury

    Background:

    • Methyldopa is a medication commonly prescribed for hypertension.
    • Drug-induced liver injury (DILI) is a significant concern in pharmacotherapy.

    Purpose of the Study:

    • To investigate the direct relationship between methyldopa administration and liver damage.
    • To characterize the clinical presentation and outcomes of methyldopa-induced hepatotoxicity.

    Main Methods:

    • Case series describing twenty patients with suspected methyldopa-related liver injury.
    • Clinical observation of patient recovery after drug withdrawal and assessment of recurrence upon re-challenge.

    Main Results:

    • Twenty patients presented with liver damage attributed to methyldopa.

    Related Experiment Videos

  • Sixteen patients developed hepatitic syndromes, with four experiencing recurrent jaundice upon methyldopa re-challenge.
  • Two fatalities were linked to methyldopa, including one in a patient with underlying cirrhosis.

    • Conclusions:

    • Methyldopa can be directly associated with significant liver damage, including hepatitic syndromes and jaundice.
    • Recurrence of liver injury is possible with re-exposure to methyldopa.
    • Clinicians should be vigilant for methyldopa-induced hepatotoxicity, especially in patients with pre-existing liver conditions.