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[Isolated hepatosplenic tuberculosis: 1 case].

G Emanuelli, G Calcamuggi, G Cestonaro

Schweizerische Medizinische Wochenschrift

|April 14, 1979

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A rare case of hepatic tuberculosis in a young woman was diagnosed and successfully treated. Prompt antituberculous and steroid therapy led to the resolution of inflammatory liver lesions.

Area of Science:

Hepatology
Infectious Diseases
Pathology

Background:

Tuberculosis (TB) can present with diverse extrapulmonary manifestations.
Hepatic involvement in TB, while uncommon, poses diagnostic challenges.

Observation:

A 27-year-old woman presented with fever, malaise, weight loss, and hepatosplenomegaly.
Diagnostic imaging and surgical exploration revealed inflammatory liver and spleen lesions.
Histopathology showed caseating granulomata in hepatic tissue, with negative stains for common pathogens.

Findings:

Microscopic caseating granulomata in liver tissue.
Negative cultures for mycobacteria and fungi.
Rapid clinical and radiological improvement with antituberculous and steroid therapy.

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Implications:

This case highlights the importance of considering tuberculosis in the differential diagnosis of unexplained hepatosplenomegaly and liver lesions.
Early diagnosis and appropriate treatment are crucial for favorable outcomes in hepatic tuberculosis.
The combination of antituberculous therapy and corticosteroids can be effective in managing this condition.