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Related Experiment Videos

Simple analgesics for arthritis.

E C Huskisson

    British Medical Journal
    |October 26, 1974
    PubMed
    Summary
    This summary is machine-generated.

    This study found that aspirin, Codis, and Distalgesic were the most effective analgesics for rheumatoid arthritis pain relief. Placebo effectiveness was influenced by timing and color, with red soluble placebo being most effective.

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    Area of Science:

    • Pharmacology
    • Rheumatology
    • Clinical Trials

    Background:

    • Rheumatoid arthritis (RA) is a chronic inflammatory disease causing pain and joint damage.
    • Effective pain management is crucial for improving the quality of life in RA patients.
    • Evaluating analgesic efficacy requires robust and sensitive methodologies.

    Purpose of the Study:

    • To assess the efficacy of various simple analgesics in patients with rheumatoid arthritis.
    • To compare the effectiveness of pain relief scores versus patient preference as outcome measures.
    • To investigate the influence of placebo administration timing and characteristics on perceived pain relief.

    Main Methods:

    • A consistent polyad design was employed for single-dose administration of analgesics.

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  • Pain relief scores were systematically recorded to measure analgesic effectiveness.
  • Patient preference was also recorded as a secondary measure of efficacy.

    • Main Results:

    • Aspirin, Codis, and Distalgesic demonstrated superior efficacy compared to placebo.
    • Paracetamol, pentazocine, and Ciba 44,328 showed intermediate effectiveness.
    • Placebo administered after an active analgesic was more effective than when given prior, irrespective of patient blinding or tablet appearance.

    Conclusions:

    • Pain relief scores are a more reliable indicator of analgesic effectiveness in RA than patient preference.
    • Specific analgesics like aspirin, Codis, and Distalgesic offer significant pain relief for rheumatoid arthritis.
    • The placebo effect in pain management is complex and can be modulated by factors such as administration timing and formulation characteristics (e.g., color).