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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Treatment of hypertension: state of the art in 1979

E D Freis

    Clinical Science (London, England : 1979)
    |December 1, 1979
    PubMed

    Insights

    Hypertension treatment is effective in preventing complications, with lower diastolic blood pressure targets now recommended. New and established drugs offer promising advancements in managing high blood pressure.

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Previous studies, including the Veterans Administration Co-operative Study, established the efficacy of hypertension treatment.
    • Subsequent trials have expanded on these findings, incorporating diverse patient populations and varying disease severity.

    Purpose of the Study:

    • To review the extended findings of hypertension treatment trials.
    • To assess the evolving targets for beneficial blood pressure reduction.
    • To highlight recent pharmacological advancements in hypertension management.

    Main Methods:

    • Analysis of data from subsequent clinical trials following the Veterans Administration Co-operative Study.
    • Comparison of treatment effectiveness across different patient demographics and disease profiles.
    • Review of emerging and established pharmacological agents for hypertension.

    Main Results:

    • Hypertension treatment effectively prevents most complications, excluding myocardial infarction and sudden death.
    • The optimal diastolic blood pressure target for beneficial effects has been lowered from 105 mmHg to 100 mmHg, as evidenced by larger trials.
    • Beta-adrenoreceptor-blocking drugs show potential in reducing sudden death and fatal myocardial infarction, warranting further investigation.

    Conclusions:

    • Current hypertension treatment strategies are effective, with evolving targets for improved outcomes.
    • New pharmacological agents and the re-evaluation of older drugs, like reserpine in combination with diuretics, enhance treatment options.
    • The field of hypertension management is advancing, with expectations for continued progress.

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