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Related Experiment Videos

Cryptococcal meningitis and internal ophthalmoplegia.

R L Lesser, R M Simon, H Leon

    American Journal of Ophthalmology
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

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    A 17-year-old treated for systemic lupus erythematosus developed cryptococcal meningitis and ophthalmoplegia. Intravenous amphotericin successfully treated the infection and neurological symptoms, suggesting third nerve involvement.

    Area of Science:

    • Neurology
    • Infectious Diseases
    • Ophthalmology

    Background:

    • Systemic lupus erythematosus (SLE) management often involves immunosuppressive therapy.
    • Immunosuppression can increase the risk of opportunistic infections like Cryptococcus.

    Observation:

    • A 17-year-old female patient with SLE on prednisone and azathioprine presented with fever and hallucinations.
    • She subsequently developed internal ophthalmoplegia, pupillary dilation, and bilateral lateral rectus palsy.

    Findings:

    • Diagnosis of cryptococcal meningitis was confirmed.
    • Treatment with intravenous amphotericin led to the resolution of papilledema, palsies, and ophthalmoplegia.

    Implications:

    • This case highlights a rare neurological complication of immunosuppression in SLE patients.

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  • It underscores the importance of considering opportunistic infections in immunocompromised individuals presenting with neurological and ophthalmological signs.
  • The findings suggest that the internal ophthalmoplegia was likely caused by inflammation affecting the third cranial nerves at the brain's base.