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Updated: Jul 17, 2026
05:52
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
Sulpiride in tardive dyskinesia.
Psychopharmacology
|January 1, 1979
Summary
Sulpiride, a selective dopamine receptor antagonist, effectively reduced tardive dyskinesia in patients. This treatment showed significant improvement without worsening parkinsonism, offering a promising therapeutic avenue.
Area of Science:
- Neuroscience
- Pharmacology
- Movement Disorders
Background:
- Tardive dyskinesia (TD) is often treated with dopaminergic receptor blockers.
- These treatments can paradoxically increase parkinsonism symptoms.
Purpose of the Study:
- To evaluate the efficacy and safety of sulpiride in treating tardive dyskinesia.
- To investigate sulpiride's effect on parkinsonism in patients with TD.
Main Methods:
- A double-blind, placebo-controlled trial involving 11 patients with tardive dyskinesia.
- Administration of sulpiride at doses ranging from 400 to 2100 mg/day.
- Assessment of tardive dyskinesia and parkinsonism scores, including eye blinking rates.
Main Results:
- Sulpiride significantly reduced tardive dyskinesia scores (P < 0.01).
- No significant increase in parkinsonism was observed, though three patients experienced mild worsening of hypokinesia and tremor.
- TD and parkinsonism scores reverted to baseline during the placebo phase.
Conclusions:
- Sulpiride selectively reduces tardive dyskinesia without significantly exacerbating parkinsonism.
- Results support the hypothesis of multiple dopamine receptor populations in extrapyramidal control.
- Sulpiride serves as a valuable tool for understanding dopamine receptor subtypes and developing targeted therapies.
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