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Infantile spasms in an infant resolved after treatment with corticotropin and surgical removal of a choroid plexus papilloma. The infant experienced significant clinical and electroencephalographic improvements, leading to full recovery.
Area of Science:
- Pediatric Neurology
- Neuro-oncology
Background:
- Infantile spasms syndrome (ISS) is a severe epilepsy syndrome in infants.
- Hypsarrhythmia on electroencephalography (EEG) is a characteristic finding.
- Choroid plexus papillomas are rare tumors that can cause neurological symptoms.
Purpose of the Study:
- To report a case of infantile spasms associated with a choroid plexus papilloma.
- To describe the treatment and outcome in this unique case.
Main Methods:
- A 7-month-old infant diagnosed with infantile spasms syndrome was treated with corticotropin.
- EEG monitoring was performed to assess neurological abnormalities.
- Surgical resection of a left lateral ventricle choroid plexus papilloma was performed.
Main Results:
- Corticotropin treatment led to improvement in clinical symptoms and EEG abnormalities.
- Surgical removal of the choroid plexus papilloma resulted in complete clinical recovery.
- The infant was seizure-free, developmentally and neurologically normal one year post-surgery.
Conclusions:
- Choroid plexus papilloma can be a treatable cause of infantile spasms syndrome.
- A combination of medical and surgical treatment can lead to excellent outcomes.
- Early diagnosis and intervention are crucial for managing complex pediatric neurological conditions.
Abstract:
A 7-month-old infant had the infantile spasm syndrome, consisting of flexor and extensor spasms, developmental delay, and hypsarrhythmia. Corticotropin produced delay, and hypsarrhythmia. Corticotropin produced improvement in the clinical symptoms and reverted the generalized electroencephalographic abnormalities to more focal ones. Removal of a choroid plexus papilloma of the left lateral ventricle was followed by clinical recovery. One year later the child was normal developmentally and neurologically and was seizure free on anticonvulsant therapy.