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Transfer factor is ineffective in amyotrophic lateral sclerosis.

M R Olarte, J C Gersten, J Zabriskie

    Annals of Neurology
    |April 1, 1979
    PubMed
    Summary

    Transfer factor did not show therapeutic value for amyotrophic lateral sclerosis (ALS) patients in a double-blind study. Neurological function scores did not significantly differ between transfer factor and placebo groups.

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    Area of Science:

    • Neurology
    • Immunology

    Background:

    • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
    • Investigating novel therapeutic agents for ALS is crucial.

    Purpose of the Study:

    • To evaluate the efficacy of transfer factor as a treatment for amyotrophic lateral sclerosis (ALS).

    Main Methods:

    • A double-blind, placebo-controlled study involving 66 ALS patients.
    • Monthly administration of transfer factor or placebo.
    • Structured rating scores of neurological function were recorded and analyzed.

    Main Results:

    • No statistically significant difference in neurological function scores between the transfer factor and placebo groups.
    • Transfer factor demonstrated no evidence of therapeutic benefit in ALS patients.

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  • Over two-thirds of patient deterioration occurred within the first six months.

    • Conclusions:

    • Transfer factor is not an effective treatment for amyotrophic lateral sclerosis.
    • The rapid progression in the initial months suggests shorter trial durations may be feasible for other ALS therapies.