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Updated: Aug 17, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
[Unusual forms of collagen fibrils in dermatoses]
Abstract:
Electron microscopic examinations of the skin from foci of lesions in scleroderma, psoriasis, parapsoriasis, and lupus erythematosus revealed two types of unusual collagen structures consisting of loosely packed fibrils 5--8 nm in diameter with a cross-striation period of 150--170 and 80--90 nm. The former were localized in the epi- or perineurium of pulpless nervous fibers of the derma, the latter among collagen fibers. These structures appear to occur rather widely in collagen metabolism disorders (tumours of neurogenic origin, some skin tumours, collagen diseases).
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