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Giant papillary conjunctivitis with ocular prostheses.

B D Srinivasan, F A Jakobiec, T Iwamoto

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |May 1, 1979
    PubMed
    Summary
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    Giant papillary conjunctivitis can affect wearers of ocular prostheses, not just contact lenses. This condition involves inflammation and may be linked to an immune response.

    Area of Science:

    • Ophthalmology
    • Immunology

    Background:

    • Giant papillary conjunctivitis (GPC) is typically associated with contact lens wear.
    • The condition involves inflammation of the upper eyelid's tarsal conjunctiva.

    Observation:

    • Seven patients with ocular prostheses (corneal shells, postenucleation prostheses, keratoprostheses) developed GPC.
    • Papillary changes were observed in the upper eyelids after prolonged prosthesis use.

    Findings:

    • The observed GPC in prosthesis wearers expands the known spectrum of the disease.
    • Inflammatory infiltrates were characterized by basophils and mast cells, suggesting an antigen-antibody mechanism.
    • Papillary changes were not always symptomatic and showed limited reversibility.

    Implications:

    Related Experiment Videos

    • This study highlights the need to consider GPC in patients with ocular prostheses.
    • The findings suggest an immune-mediated response, potentially involving epithelial mucin, in GPC development.
    • Understanding these mechanisms can inform management strategies for prosthesis-related ocular surface disease.