Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Buccal absorption of ergotamine.

J M Sutherland, W D Hooper, M J Eadie

    Journal of Neurology, Neurosurgery, and Psychiatry
    |October 1, 1974
    PubMed
    Summary

    Buccal administration of ergotamine showed minimal absorption in the mouth. Low solubility at saliva pH limits therapeutic absorption, even after five minutes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A cost-utility study of elective haemorrhoidectomies in Canada.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2024
    Same author

    Two alternative methods for the retrieval of somatic cell populations from the mouse ovary.

    Molecular human reproduction·2021
    Same author

    Occurrence of nodulation in the Leguminosae.

    The New phytologist·2021
    Same author

    Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line.

    Reproduction, fertility, and development·2020
    Same author

    Health and quality of life among a cohort of patients having lateral internal sphincterotomy for anal fissures.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
    Same author

    Discharge destination following hip fracture in Canada among previously community-dwelling older adults, 2004-2012: database study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019

    Area of Science:

    • Pharmacokinetics
    • Drug Absorption
    • Oral Mucosa

    Background:

    • Ergotamine is used for treating migraines.
    • Buccal drug delivery offers an alternative to oral administration.
    • Understanding buccal absorption is crucial for optimizing drug efficacy.

    Purpose of the Study:

    • To investigate the absorption rate of ergotamine from the buccal mucosa.
    • To determine factors influencing ergotamine buccal absorption.

    Main Methods:

    • Studied ergotamine disappearance from the mouth in seven subjects.
    • Accounted for non-absorptive losses.
    • Analyzed absorption as a function of pH and drug concentration.

    Main Results:

    • Ergotamine absorption across the buccal mucosa is a passive, pH-dependent process.
    • Absorption was independent of ergotamine concentration and caffeine presence.
    • Low ergotamine solubility at salivary pH significantly limited buccal absorption.

    Conclusions:

    • Therapeutically relevant absorption of ergotamine via the buccal mucosa is unlikely.
    • Buccal administration of ergotamine may not be an effective delivery route due to poor solubility and absorption.

    Related Experiment Videos