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Disseminated intravascular coagulation associated with toxic epidermal necrolysis (Lyell's syndrome)

J Kvasnicka, J Rezác, J Svejda

    The British Journal of Dermatology
    |May 1, 1979
    PubMed

    Evidence of disseminated intravascular coagulation was recorded in eight patients with toxic epidermal necrolysis (TEN)--Lyell's syndrome. Patients were treated with low doses of heparin in combination with the usual treatment of TEN, i.e. maintenance of fluid and electrolyte balance, systemic corticosteroids, antibiotics and aseptic dressings, in the Intensive Care Unit environment. It is suggested that the alteration of haemostasis and inter-related biological systems, such as activation of components of complement, kinins and immunoglobulins, may affect the outcome of TEN.

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