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The two-locus model with sex differences in recombination.

C Strobeck

    Genetics
    |October 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    Investigating genetic models with differing male and female recombination rates reveals stability criteria. Unequal recombination rates can increase linkage disequilibrium at equilibrium compared to equal rates.

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    Area of Science:

    • Population genetics
    • Quantitative genetics

    Background:

    • The two-locus model is fundamental in population genetics for understanding gene interactions.
    • Recombination rates can vary between sexes, influencing genetic linkage.

    Purpose of the Study:

    • To determine the stability criteria for genetic equilibrium in a two-locus model with unequal recombination rates.
    • To analyze equilibrium genetic disequilibrium (D) under different fitness models and recombination scenarios.

    Main Methods:

    • Mathematical analysis of the two-locus model.
    • Derivation of equilibrium conditions for D=0 and D≠0.
    • Comparison of results with and without sex-specific recombination.

    Main Results:

    • Stability criteria for D=0 are identical to the standard model when using the average recombination rate.

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  • For symmetric fitness, the absolute value of D at equilibrium is larger when male and female recombination rates differ.

    • Conclusions:

    • Sex-specific recombination rates do not alter stability criteria at D=0 if the average rate is used.
    • Divergent recombination rates can enhance linkage disequilibrium at equilibrium, impacting genetic variation.