Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and unusual catecholamine-containing structures in the mouse brain.

D T Masuoka, G Jonsson, C E Finch

    Brain Research
    |June 22, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Higher blood lipid levels after the transition to menopause in two forager-horticulturalist populations.

    Evolution, medicine, and public health·2025
    Same author

    APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.

    Acta neuropathologica communications·2019
    Same author

    Prenatal and early life exposure to air pollution induced hippocampal vascular leakage and impaired neurogenesis in association with behavioral deficits.

    Translational psychiatry·2018
    Same author

    Comment on "The plateau of human mortality: Demography of longevity pioneers".

    Science (New York, N.Y.)·2018
    Same author

    Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models.

    Translational psychiatry·2017
    Same author

    Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016.

    Journal of Alzheimer's disease & Parkinsonism·2017
    Same journal

    IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

    Brain research·2026
    Same journal

    Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

    Brain research·2026
    Same journal

    Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

    Brain research·2026
    Same journal

    Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

    Brain research·2026
    Same journal

    Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

    Brain research·2026
    Same journal

    Emotions, the amygdala, and the right hemisphere.

    Brain research·2026
    See all related articles

    Senescent mice brains show unusual catecholamine (CA) accumulations in nerve terminals, termed large, intensely fluorescent spots (LIFS). These findings suggest LIFS may indicate age-related axonal degeneration.

    Area of Science:

    • Neuroscience
    • Histochemistry
    • Aging Research

    Background:

    • Aging is associated with complex changes in brain structure and function.
    • Catecholamines (CA) play crucial roles in neuronal signaling and are implicated in age-related neurological processes.

    Purpose of the Study:

    • To investigate age-related changes in catecholamine distribution in the brain.
    • To characterize novel fluorescent structures observed in senescent mouse brains.

    Main Methods:

    • Histochemical fluorescence technique (Falck-Hillarp) applied to C57BL/6J mouse brains aged 4, 8, and 20-29 months.
    • Spectral analysis and pharmacological procedures to identify the nature of fluorescent structures.
    • Quantitative assessment of fluorescent spot distribution and number.

    Related Experiment Videos

    Main Results:

    • Numerous large, intensely fluorescent spots (LIFS) were observed in senescent mice brains.
    • Spectral and chemical analyses confirmed LIFS fluorescence is due to catecholamines (CA), not aging pigment.
    • LIFS were found in nerve axons or terminals, with increasing numbers in the hypothalamus with age.

    Conclusions:

    • LIFS represent age-related, unusual CA accumulation in enlarged axonal or terminal portions.
    • These accumulations may be associated with spontaneous axonal degeneration during aging.
    • The study provides insights into the neurochemical changes occurring in the aging brain.