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Hairy cell leukemia: an autopsy study.

J W Vardiman, D Variakojis, H M Golomb

    Cancer
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Pulmonary infiltration by hairy cell leukemia (HCL) cells is a significant finding in autopsy cases. This leukemic cell infiltration can lead to severe pulmonary insufficiency and death.

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    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Hairy cell leukemia (HCL) is a rare chronic B-cell leukemia.
    • While HCL commonly affects the spleen, liver, and bone marrow, extranodal involvement can occur.

    Purpose of the Study:

    • To investigate the autopsy findings in patients with hairy cell leukemia.
    • To characterize the extent and locations of leukemic cell infiltration in HCL.

    Main Methods:

    • Autopsy examination of 5 patients diagnosed with hairy cell leukemia.

    Main Results:

    • All patients exhibited pulmonary infiltration by leukemic cells, severe in one case, causing death from pulmonary insufficiency.
    • Additional sites of infiltration included peripancreatic connective tissue (all cases), kidneys (3 cases), pericardium (2 cases), and skin (1 case).

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  • Prominent association of plasma cells with neoplastic cells was observed, and one patient showed atypical large cells in lymph nodes and pericardium.

    • Conclusions:

    • Pulmonary infiltration is a common and potentially fatal manifestation of hairy cell leukemia.
    • Extranodal involvement in HCL can be widespread, affecting various organs.
    • The presence of large, bizarre cells warrants further investigation into potential transformation or a secondary neoplasm.