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Carcinoma arising in eccrine spiradenoma.

H L Evans, D Su, J L Smith

    Cancer
    |May 1, 1979
    PubMed
    Summary
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    Carcinoma can arise in eccrine spiradenoma, a rare skin tumor. Microscopic examination confirmed this malignant transformation in two patients with changing skin nodules, with one case showing lymph node metastasis.

    Area of Science:

    • Dermatopathology
    • Surgical Oncology

    Background:

    • Eccrine spiradenoma is a benign adnexal neoplasm.
    • Malignant transformation of eccrine spiradenoma is exceptionally rare.

    Observation:

    • Two patients presented with long-standing cutaneous nodules exhibiting recent changes.
    • Surgical excision was performed due to the observed nodule alterations.

    Findings:

    • Microscopic examination revealed carcinoma intimately associated with benign eccrine spiradenoma.
    • The histological findings suggest the carcinoma originated from the eccrine spiradenoma.
    • One patient demonstrated lymph node metastasis, indicating potential for advanced disease.

    Implications:

    • This highlights the importance of vigilance for malignant change in persistent adnexal lesions.

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  • Early diagnosis and complete excision are crucial for managing eccrine spiradenoma carcinoma.
  • Metastasis risk underscores the need for thorough staging and follow-up in these rare cases.