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Related Experiment Videos

Carcinoembryonic antigen-like substance derived from human prostate.

R D Williams, D L Bronson, A D Myl

    Cancer Research
    |July 1, 1979
    PubMed
    Summary

    Researchers identified a carcinoembryonic antigen-like substance in human prostate tissues and cell cultures. This prostate-derived substance differs from colon-derived antigen and may be prostate-specific.

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    Area of Science:

    • Biochemistry
    • Oncology
    • Urology

    Background:

    • Carcinoembryonic antigen-like substance (CEAS) is found in human prostatic epithelial cell cultures.
    • CEAS is also present in extracts from both benign and malignant prostate tissues.

    Purpose of the Study:

    • To characterize the CEAS found in prostate tissue and cell cultures.
    • To determine if prostate-derived CEAS is distinct from colon-derived carcinoembryonic antigen (CEA).

    Main Methods:

    • Column chromatography was used to analyze and compare prostate-derived CEAS with colon-derived CEA.
    • Molecular weight estimation was performed on the prostate-derived CEAS.

    Main Results:

    • Prostate-derived CEAS from cultured cells is identical to that found in tissue extracts.

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  • Prostate-derived CEAS is biochemically distinct from colon-derived CEA.
  • The molecular weight of prostate-derived CEAS is estimated to be greater than 5 x 10^5 Da.

    • Conclusions:

    • The CEAS found in prostate tissue and cell cultures is a unique entity.
    • Prostate-derived CEAS exhibits characteristics suggesting it may be a prostate-specific antigen.