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Concentric laminated bodies in muscle pathology
Pathologia Europaea
|January 1, 1974
Summary
Concentric laminated bodies, complex filamentous structures, are observed in various muscle diseases and even in normal muscle fibers of mothers with myopathy. Their myofilamentous nature is considered probable over mitochondrial or lipid origins.
Area of Science:
- Muscle pathology
- Cellular ultrastructure
- Skeletal muscle disorders
Background:
- Concentric laminated bodies (CLBs) are ultrastructural findings in muscle tissue.
- Their presence has been noted in various neuromuscular disorders.
- Previous reports on CLBs are limited, necessitating further investigation.
Purpose of the Study:
- To describe CLBs in new cases of muscle diseases.
- To review existing literature on CLBs.
- To investigate the nature and origin of CLBs.
Main Methods:
- Histopathological examination of muscle biopsies.
- Review of published literature on CLBs.
- Ultrastructural analysis of muscle fibers.
Main Results:
- CLBs were identified in five cases of muscle diseases (one prior, four new).
- These bodies were found in abnormal skeletal muscle across different disorders.
- CLBs were also observed in normal muscle fibers of mothers with myopathic children.
- CLBs exhibit a complex filamentous structure.
Conclusions:
- Concentric laminated bodies appear to be non-specific findings in muscle pathology.
- Their presence in normal muscle fibers of unaffected mothers suggests a potential genetic or familial link.
- The myofilamentous nature of CLBs is considered more likely than mitochondrial or lipid origins.