An ultraviolet spectrophotometric procedure for the routine determination of naproxen

1. A procedure for the routine assay of Naproxen in serum by ultraviolet spectrophotometry is presented. The absorption coefficient (A1 1% cm) of Naproxen in methanol at 261 nm was found to be 216. 2. The Naproxen procedure appears to be relatively free from interferences of commonly coadministered medications. Salicylate interference is eliminated by a modified procedure. 3. Concentrations of Naproxen in a limited number (40) of clinical samples ranged from non-detected to 12.5 mg/dl. The therapeutic concentration appears to be 4 to 6 mg/dl (174-260 mumol/L).