[Test of cellulose and cellulose derivatives for carcinogenic activity in rats, mice and rabbits]

Activated cellulose, p-aminobenzylcellulose, p-hydroxybenzylcellulose, cellulose-m-aminobenzoxymethylether and cellulose-m-hydroxybenzoxymethylether which are used as highmolecular inert components for the preparation of immunoadsorbents, have been tested for carcinogenic activity in Wistar-rats and CBA-mice by the subcutaneous and intramuscular route of administration. In the same manner the coupling products have been tested in rats, mice and rabbits of diazotized p-aminobenzylcellulose and cellulose-m-aminobenzoxymethylether with a) human gammaglobulin [(cellulose-p-benzylether)-azogammaglobulin and (cellulose-m-benzoxymethylether)-azogammaglobulin respectively] and b) 1-(m-hydroxyphenyl)-flavozole derivatives of saccharides of the isomaltodextrin- and maltodextrin series [saccharide-1-(3 ft.-hydroxy-4 ft.-(resp.-6 ft.-or-2 ft.-) [cellulose-p-benzylether]-azophenyl)-flavazoles and saccharide-1-(3 ft.-hydroxy-4 ft.-(resp. -6 ft;-or-2 ft.-) [cellulose-m-benzoxymethylether]-azophenyl)-flavazoles with isomaltotriose, isomaltotetraose, isomaltopentaose, isomaltohexaose, isomaltooctaose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltooctaose as saccharide moieties]. No tumours were found in rabbits. No statistical significant difference could be stated between the tumour incidence of experimental animals and controls in the rat and mouse groups.