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Related Experiment Videos

Intoxication with ajmaline in an infant.

G Ben-Shachar, Y Kishon

    Chest
    |July 1, 1979
    PubMed
    Summary

    Ajmaline overdose in an infant caused seizures and cardiac issues. Prompt resuscitation and supportive care led to full recovery, highlighting the need for continuous monitoring in such cases.

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    Area of Science:

    • Pediatric Cardiology
    • Clinical Toxicology

    Background:

    • Ajmaline is an antiarrhythmic drug with a narrow therapeutic index.
    • Infant physiology presents unique challenges in drug metabolism and response.

    Observation:

    • A case of ajmaline overdose in an infant is presented.
    • Clinical manifestations included atactic gait, seizures, loss of consciousness, apnea, supraventricular tachycardia, left bundle-branch block, and prolonged Q-T interval.

    Findings:

    • Cardiopulmonary resuscitation, gastric lavage, and forced diuresis were effective interventions.
    • Complete recovery was achieved in the infant patient.

    Implications:

    • Continuous electrocardiographic monitoring is crucial for managing ajmaline overdose.
    • Consideration of cardiac pacing, respiratory support, and antiarrhythmic therapy is essential.