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Related Experiment Videos

pH-controlled hydrogen-bonding.

J L Wood

    The Biochemical Journal
    |December 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    The study explores hydrogen bonding between bases and conjugate acids, finding complexation is sharply pH-dependent at low levels. At higher complexation, the pH dependence broadens, impacting chemical equilibria.

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    Area of Science:

    • Physical Chemistry
    • Chemical Thermodynamics
    • Biophysical Chemistry

    Background:

    • Hydrogen bonding plays a crucial role in molecular interactions and chemical processes.
    • Understanding the pH-dependence of these interactions is vital for various chemical and biological systems.
    • The dissociation constant (pK(a)) of conjugate acids influences acid-base equilibria.

    Purpose of the Study:

    • To investigate the pH-dependence of hydrogen-bonding complexation between a base and its conjugate acid.
    • To characterize the relationship between complexation degree and pH under varying conditions.
    • To compare this pH-dependence to protonation phenomena in dibasic acids.

    Main Methods:

    • Theoretical analysis of hydrogen-bonding equilibria.

    Related Experiment Videos

  • Mathematical modeling based on dissociation constants (pK(a)) and association constants (K).
  • Exploration of the function (1+coshp)(-1) where p=2.303 (pK(a)-pH).

    • Main Results:

    • At low complexation, the amount of base complexed shows sharp pH-dependence, proportional to (1+coshp)(-1).
    • As complexation increases, the pH-dependence curve broadens and becomes flat-topped.
    • More than half the base remains complexed over a pH range of approximately pK(a) +/- log(KC).

    Conclusions:

    • The degree of hydrogen bonding between bases and conjugate acids is significantly pH-dependent.
    • The observed pH-dependence profile shifts from sharp to broad as complexation levels rise.
    • Similarities exist between this hydrogen-bonding behavior and the mono-protonation of dibasic acids.