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A retrospective survey of the complications of mumps
Abstract:
A retrospective survey is described of 2,482 cases of mumps (1,513 males and 969 females) treated in a number of infectious disease units in England and Wales. About half the patients were under 15 years of age. Complications were recorded in 42 per cent of all cases (53 per cent of males and 25 per cent of females), the commonest complication in both sexes being involvement of the central nervous system. Three patients died, but in two of these there was serious underlying illness unrelated to mumps and in the remaining case a review of the records suggests, in retrospect, some doubt about the diagnosis of mumps. Deafness due to involvement of the eighth cranial nerve was the only permanent sequel recorded and occurred in five patients.From the results of this survey it is concluded that there is little need for general vaccination against mumps, although there might be an indication for vaccinating certain groups of the male population.
Insights
This mumps study found complications in 42% of cases, with central nervous system involvement most common. General mumps vaccination is not recommended, but targeted vaccination for males may be considered.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- Mumps is a viral infection that can lead to various complications.
- Understanding the incidence and outcomes of mumps is crucial for public health strategies.
Purpose of the Study:
- To analyze the clinical features and outcomes of a large cohort of mumps cases.
- To evaluate the necessity of general vaccination against mumps.
Main Methods:
- Retrospective survey of 2,482 mumps cases treated in infectious disease units in England and Wales.
- Data collection on patient demographics, complications, and long-term sequelae.
Main Results:
- 42% of patients experienced complications, with males (53%) more affected than females (25%).
- Central nervous system involvement was the most frequent complication in both sexes.
- Deafness was the only permanent sequel, affecting five patients. Three deaths occurred, with questionable mumps diagnosis or unrelated underlying illnesses in two cases.
Conclusions:
- Routine mumps vaccination is not strongly indicated for the general population.
- Vaccination may be considered for specific male demographic groups due to higher complication rates.