Synthesis and isolation of a glucagon antagonist

(S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives.

Organic letters·2001

Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.

European journal of pharmacology·2000

Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads.

Current medicinal chemistry·2000

4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics.

Organic letters·2000

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

Journal of medicinal chemistry·2000

Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin.

Journal of neurochemistry·2000

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin.

FEBS letters·2026

Partial depletion of plasminogen activator inhibitor-1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high-fat-fed female mice.

FEBS letters·2026

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

FEBS letters·2026

The impact of aging on the gut-liver axis in health and disease.

FEBS letters·2026

Autophagy and mitophagy in pancreatic β-cell homeostasis and their involvement in diabetes pathophysiology.

FEBS letters·2026

Oxidative modification of the D1 residue 332H during photoinactivation drives photosystem II turnover.

FEBS letters·2026

Electron-withdrawing group effects on the structural, electronic, reactivity, and binding characteristics of triazolopyrimidine herbicides: a comparative study of diclosulam, cloransulam-methyl, and cloransulam.

RSC advances·2026

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma.

Frontiers in bioinformatics·2026

Sulfonamide-Based 2-Amino-1,3,4-Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation.

Drug development research·2026

Revisiting multicomponent Doebner and Povarov quinoline synthesis for modern-day drug-discovery.

Organic & biomolecular chemistry·2026

Salvinorin A in humans: A systematic review of pharmacokinetics, pharmacodynamics, and safety.

Journal of psychopharmacology (Oxford, England)·2026

Organic photosensitizers for antifungal therapy: structural diversity and emerging applications.

Chemical communications (Cambridge, England)·2026

Related Experiment Videos

Synthesis and isolation of a glucagon antagonist

Related Concept Videos

(S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives.

Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.

Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads.

4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics.

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.

Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin.

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin.

Partial depletion of plasminogen activator inhibitor-1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high-fat-fed female mice.

Ligand-dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry.

The impact of aging on the gut-liver axis in health and disease.

Autophagy and mitophagy in pancreatic β-cell homeostasis and their involvement in diabetes pathophysiology.

Oxidative modification of the D1 residue 332H during photoinactivation drives photosystem II turnover.

Electron-withdrawing group effects on the structural, electronic, reactivity, and binding characteristics of triazolopyrimidine herbicides: a comparative study of diclosulam, cloransulam-methyl, and cloransulam.

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma.

Sulfonamide-Based 2-Amino-1,3,4-Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation.

Revisiting multicomponent Doebner and Povarov quinoline synthesis for modern-day drug-discovery.

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Synthesis and isolation of a glucagon antagonist

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