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Cimetidine effects on prolactin release and production.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|March 1, 1979
Summary
Cimetidine (1600 mg daily for three months) slightly increased prolactin but did not affect other hormone levels or responses. The drug may facilitate prolactin release, not synthesis.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Cimetidine is a histamine H2 receptor antagonist.
- Intravenous cimetidine is known to cause transient hyperprolactinemia.
Purpose of the Study:
- To investigate the long-term effects of oral cimetidine on prolactin and related hormones.
- To determine if cimetidine influences hormone synthesis or release.
Main Methods:
- Oral administration of cimetidine (1600 mg daily) for three months.
- Measurement of basal prolactin, thyroid hormones, and sex hormones.
- Assessment of hormone responses to releasing hormone stimulation.
Main Results:
- A slight, non-significant increase in basal prolactin levels was observed.
- No significant changes in basal thyroid or sex hormone levels were detected.
- Hormonal responses to releasing hormone stimulation remained unchanged.
Conclusions:
- Oral cimetidine may facilitate prolactin release but does not appear to affect its synthesis.
- Long-term oral cimetidine does not significantly alter basal levels of thyroid and sex hormones or their responses to stimulation.