Structure activity relationships in a series of anti-neoplastic dinitrophenyl aziridines--protein binding studies

Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

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Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment.

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Cell cycle specific induction of HL-60 cell differentiation and apoptosis by mycophenolic acid.

Cell death and differentiation·2006

Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

Oncogene·2001

Macrophage-intrinsic STAT3 drives LPS-induced acute lung injury: allosteric blockade by K116 and genetic validation via conditional knockout.

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PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.

Biochemical pharmacology·2026

Celastrol induces mitochondrial apoptosis in hepatocellular carcinoma by suppressing LRP6-associated Wnt/β-catenin signaling.

Biochemical pharmacology·2026

Zinc gluconate attenuates oxaliplatin-induced pulmonary injury via suppressing the TLR4/NF-κB signaling.

Biochemical pharmacology·2026

Colchicine reduces aortic dissection and aneurysm formation in mice by inhibiting the IL-17A/RA-MAPK pathway.

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RNF5: an emerging therapeutic target for modulating immunity and metabolism.

Biochemical pharmacology·2026

Mass Chlorfenapyr Poisoning: A Family Cluster Case Report.

Journal of emergency nursing·2026

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ACS omega·2026

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Integrated molecular docking, simulation dynamics and cytotoxicity assays of Desmodium gangeticum-derived phytochemicals for multi-target cancer therapy.

In silico pharmacology·2026

Synthesis, Biological Evaluation, and Molecular Modeling of Novel Pyrimidine Scaffolds as Prospective Anticancer and Antimicrobial Agents.

ChemMedChem·2026

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Nature computational science·2026

Related Experiment Videos

Structure activity relationships in a series of anti-neoplastic dinitrophenyl aziridines--protein binding studies

Related Concept Videos

Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.

Different cell thresholds for commitment to death: a link between carcinogenesis and drug resistance.

Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment.

Cell cycle specific induction of HL-60 cell differentiation and apoptosis by mycophenolic acid.

Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

Macrophage-intrinsic STAT3 drives LPS-induced acute lung injury: allosteric blockade by K116 and genetic validation via conditional knockout.

PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.

Celastrol induces mitochondrial apoptosis in hepatocellular carcinoma by suppressing LRP6-associated Wnt/β-catenin signaling.

Zinc gluconate attenuates oxaliplatin-induced pulmonary injury via suppressing the TLR4/NF-κB signaling.

Colchicine reduces aortic dissection and aneurysm formation in mice by inhibiting the IL-17A/RA-MAPK pathway.

RNF5: an emerging therapeutic target for modulating immunity and metabolism.

Mass Chlorfenapyr Poisoning: A Family Cluster Case Report.

Identification, Structure-Activity Relationship (SAR), and Biological Evaluation of New Chemical Series as Malaria Parasite PfGCN5 Bromodomain Inhibitors.

Influences of 5-Hydroxytryptamine Receptor Agonists on Spermatozoal Hyperactivation and In Vitro Fertilization Success in Mice.

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Related Experiment Videos

Structure activity relationships in a series of anti-neoplastic dinitrophenyl aziridines--protein binding studies

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