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[Pneumococcal serotyping. Multicentric inventory in hospital. Years 1977-1978 (author's transl)]
Abstract:
For a period of 17 months, 670 pneumococci, mostly isolated in the Paris area, have been typed with contercurrent-immunoelectrophoresis ; 338 of them come from cases of pneumonia, bacteremia, meningitis and acute otitis media. An important regrouping of the most frequent serotypes among the 83 known serotypes makes possible a vaccinal prophylaxis. The tetradecavalent vaccine which is now for sale in USA gives, in the four main pathologies of this enquiry, a coverage superior to 80 percent. Choosing the 14 most frequent serotypes of the four main pathologies of their data the authors propose the following vaccinal formula : 1, 3, 4, 5, 6, 7, 8, 10, 12, 14, 15, 18, 19, 23.
Insights
A study of 670 pneumococci strains found that a 14-valent vaccine could cover over 80% of common infections like pneumonia and meningitis. This research supports targeted pneumococcal vaccine development.
Area of Science:
- Medical Microbiology
- Immunology
- Vaccinology