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Related Experiment Videos

Total and free thyroid hormone concentrations after elective surgery.

R W Prescott, P P Yeo, M J Watson

    Journal of Clinical Pathology
    |April 1, 1979
    PubMed
    Summary

    Elective surgery, like cholecystectomy, alters thyroid hormone levels, increasing thyroxine (T4) and decreasing triiodothyronine (T3). Peripheral conversion shifts towards reverse T3, independent of cortisol changes.

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    Area of Science:

    • Endocrinology
    • Surgical Physiology

    Background:

    • Thyroid hormones play a crucial role in metabolic regulation.
    • Surgical stress can impact endocrine function, including thyroid hormone levels.

    Purpose of the Study:

    • To investigate the impact of elective cholecystectomy on thyroid hormone profiles and plasma cortisol levels.
    • To understand the changes in peripheral conversion of thyroid hormones during the perioperative period.

    Main Methods:

    • Blood samples were collected from 11 patients undergoing elective cholecystectomy.
    • Measurements included total and free thyroxine (T4), total and free triiodothyronine (T3), reverse T3, thyroid stimulating hormone, and plasma cortisol.

    Main Results:

    • Post-surgery, a significant increase in total and free T4 was observed.

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  • A significant decrease in total and free T3 was noted, with a substantial rise in reverse T3.
  • Serum thyroid stimulating hormone levels remained unchanged, and no correlation was found between cortisol and thyroid hormone changes.

    • Conclusions:

    • Elective cholecystectomy induces significant alterations in thyroid hormone distribution.
    • Peripheral conversion of T4 to T3 is diminished post-surgery, favoring reverse T3 formation.
    • Cortisol levels do not appear to directly correlate with these perioperative thyroid hormone shifts.