Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging of collagen.

J P Bentley

    The Journal of Investigative Dermatology
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Collagen cross-links stabilize connective tissue fibers. A decrease in detectable cross-links with age, despite increased tissue stability, suggests in vivo oxidation may render them undetectable.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Childhood outcomes following preterm prelabor rupture of the membranes (PPROM): a population-based record linkage cohort study.

    Journal of perinatology : official journal of the California Perinatal Association·2017
    Same author

    The influence of risk and monetary payment on the research participation decision making process.

    Journal of medical ethics·2004
    Same author

    Sale of tobacco products in pharmacies: results and implications of an empirical study.

    Journal of the American Pharmaceutical Association (Washington, D.C. : 1996)·1998
    Same author

    Quality of life assessment by community pharmacists: an exploratory study.

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·1998
    Same author

    Values, participatory democracy, and healthcare resource allocation: an application to a campus community.

    Journal of American college health : J of ACH·1995
    Same author

    The stabilization of fibrillar collagen matrices with 3,4-dihydroxyphenylalanine.

    Journal of biomedical materials research·1991
    Same journal

    Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

    The Journal of investigative dermatology·2026
    Same journal

    Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

    The Journal of investigative dermatology·2026
    Same journal

    Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

    The Journal of investigative dermatology·2026
    Same journal

    Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

    The Journal of investigative dermatology·2026
    Same journal

    The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

    The Journal of investigative dermatology·2026
    Same journal

    Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

    The Journal of investigative dermatology·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Connective Tissue Research
    • Biomaterials Science

    Background:

    • Collagen is the primary structural protein in connective tissues, providing tensile strength.
    • Covalent cross-links between collagen molecules are crucial for forming stable collagen fibers.
    • The mechanical properties of dermal connective tissue are influenced by the types and density of collagen cross-links.

    Purpose of the Study:

    • To review current knowledge on the structure and formation of collagen cross-links.
    • To correlate mechanical properties of dermal connective tissue with age-related changes in cross-links.
    • To investigate the anomaly of decreasing detectable cross-links with increasing tissue stability post-maturity.

    Main Methods:

    • Review of existing literature on collagen cross-link structure and formation.

    Related Experiment Videos

  • Correlation analysis between mechanical properties, age, and cross-link types in dermal tissue.
  • Examination of data related to in vivo oxidation of collagen cross-links.

    • Main Results:

    • Collagen cross-links are essential for the structural integrity of collagen fibers.
    • A direct correlation exists between specific cross-link types and the mechanical properties of dermal connective tissue.
    • An observed decrease in detectable cross-links after tissue maturity contradicts expectations, as mechanical stability increases.

    Conclusions:

    • The formation and structure of collagen cross-links are key to tissue mechanics.
    • Age-related changes in collagen cross-links significantly impact tissue properties.
    • In vivo oxidation of collagen cross-links may explain their reduced detectability despite increased tissue stability, suggesting a need for revised detection methodologies.