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Absorption of monoferric phytate by dogs
The Journal of Nutrition
|July 1, 1979
Summary
Monofèric phytate (MFP) iron absorption in dogs was assessed. MFP showed lower iron bioavailability than ferrous sulfate when given alone, but similar absorption to inorganic iron when consumed with food.
Area of Science:
- Nutritional Science
- Food Chemistry
- Human Health
Background:
- Wheat contains iron predominantly as monoferric phytate (MFP).
- MFP's solubility at pH 7.0+ suggests potential dietary iron availability.
- Previous research indicates MFP may be a viable iron source.
Purpose of the Study:
- To evaluate the iron absorption of monoferric phytate (MFP).
- To compare MFP iron bioavailability against ferrous sulfate and dietary inorganic iron.
- To assess MFP's suitability for iron fortification in foods.
Main Methods:
- Iron absorption was studied in adult dogs.
- A double radioisotope method and total body counting were employed.
- MFP was administered with and without food, and compared to ferrous sulfate and inorganic iron sources.
Main Results:
- When given alone, MFP iron bioavailability was lower than ferrous sulfate, especially at higher doses (15 mg).
- When consumed with food, MFP iron underwent complete isotopic exchange with the nonheme iron pool.
- MFP iron absorption equaled that of inorganic iron when added to meals for fortification purposes.
Conclusions:
- Monofèric phytate (MFP) iron shows reduced bioavailability when taken without food compared to ferrous sulfate.
- MFP iron bioavailability is comparable to inorganic iron when incorporated into meals, suggesting potential for food fortification.
- Dietary context significantly influences the absorption of MFP iron.