Lysine deficiency and voluntary exercise in the albino rat

The relationship between low dietary protein and voluntary wheel running was investigated by feeding weanling male white rats a natural diet deficient in lysine, by bioassay criterion. Lysine deficient rats ran more than those pair-fed or ad libitum fed the same diet with lysine added. Body composition of active and inactive rats on the three dietary regimens was compared. Of the carcass components, total and percent protein reduction correlated most strongly with running. Control animals matched in growth to the lysine deficient rats showed hyperactivity earlier, but to the same extent as the lysine deficient rats.