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[Iatrogenic depression (author's transl)].

J F Chevalier, D Ginestet

    L'Encephale
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Identifying drug-induced depression is challenging due to methodological difficulties. Despite common accusations, real drug-caused depression appears to be uncommon among widely used medications.

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    Area of Science:

    • Pharmacology
    • Psychiatry
    • Clinical Medicine

    Context:

    • Certain medications, including antihypertensives, oral contraceptives, appetite suppressants, and neuroleptics, are frequently implicated in causing depression.
    • Methodological challenges in identifying iatrogenic depression include accurately detecting depression and establishing a definitive link to drug administration amidst numerous confounding factors.

    Purpose:

    • To critically analyze the evidence and clinical observations regarding drug-induced depression.
    • To evaluate the methodological difficulties in diagnosing depression caused by pharmacological agents.

    Summary:

    • The literature presents contradictory evidence on drug-induced depression, with inconsistencies in specifying depression type and severity.
    • Factors such as pre-existing psychiatric disorders and the impact of underlying illness are often underestimated.

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  • Biochemical effects of implicated drugs on cerebral amines do not consistently correlate with increased depression, suggesting drug-induced depression is less common than presumed.

    • Impact:

    • Highlights the complexity of diagnosing iatrogenic depression and the need for rigorous methodology.
    • Suggests that the actual incidence of depression caused by commonly used drugs may be lower than traditionally believed.
    • Informs clinical practice regarding the differential diagnosis of depression and medication review.