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Cefaclor: clinical and bacteriological evaluation in 45 cases.

R Gómez-Lus, R Martinez-Piriz, C Espinosa

    Postgraduate Medical Journal
    |January 1, 1979
    PubMed
    Summary
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    Cefaclor effectively treated pneumonia and most urinary tract infections in patients. This study assessed cefaclor

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Urinary tract infections (UTIs) and pneumonia are common infections.
    • Antimicrobial resistance necessitates evaluating antibiotic efficacy.
    • Cefaclor is a cephalosporin antibiotic.

    Purpose of the Study:

    • To evaluate the effectiveness, tolerance, and toxicity of cefaclor.
    • To assess cefaclor in treating urinary tract infections and pneumonia.
    • To determine clinical and bacteriological outcomes.

    Main Methods:

    • Oral administration of cefaclor (1-3 g/day for 7-11 days) to 45 patients.
    • Treatment of 40 UTI cases and 5 pneumonia cases.
    • Clinical and laboratory monitoring before, during, and after treatment.

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    Main Results:

    • All 5 pneumonia patients achieved a cure.
    • Clinical and bacteriological cure in 70% (28/40) of UTI patients.
    • Tolerance and toxicity data were collected.

    Conclusions:

    • Cefaclor demonstrated significant effectiveness in treating pneumonia.
    • Cefaclor achieved a high cure rate for UTIs caused by susceptible pathogens.
    • Further investigation into cefaclor's role in infectious disease management is warranted.