Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Oxygen toxicity in a mixture with helium].

G V Troshikhin, Zh A Donina

    Kosmicheskaia Biologiia I Aviakosmicheskaia Meditsina
    |May 1, 1979
    PubMed
    Summary

    Elevated helium-oxygen (He-O2) exposure at warmer temperatures accelerated oxygen toxicity in mice, causing faster lung damage and earlier death compared to room temperature conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Causes of Hypoxemia in COVID-19.

    Journal of evolutionary biochemistry and physiology·2022
    Same author

    A Comparative Assessment of Effects of Major Mediators of Acute Phase Response (IL-1, TNF-α, IL-6) on Breathing Pattern and Survival Rate in Rats with Acute Progressive Hypoxia.

    Journal of evolutionary biochemistry and physiology·2021
    Same author

    [EFFECTS OF PROINFLAMMATORY CYTOKINE INTERLEUKIN-1P ON RESISTANCE TO ACUTE HYPOXIA].

    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2018
    Same author

    [ASSOCIATED RESPIRATORY AND HEMODYNAMICS RESPONSE TO ACUTE NORMOBARIC PROGRESSIVE HYPOXIA IN ANESTHETIZED RATS].

    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova·2016
    Same author

    The Mechanisms of Compensatory Responses of the Respiratory System to Simulated Central Hypervolemia in Normal Subjects.

    Advances in experimental medicine and biology·2014
    Same author

    Effects of inspiratory muscle training on resistance to fatigue of respiratory muscles during exhaustive exercise.

    Advances in experimental medicine and biology·2014

    Area of Science:

    • Environmental toxicology
    • Physiology
    • Gas toxicology

    Background:

    • Oxygen toxicity is a significant concern in hyperbaric and high-oxygen environments.
    • The influence of inert gases and ambient temperature on oxygen toxicity is not fully understood.

    Purpose of the Study:

    • To investigate the effect of helium-oxygen (He-O2) mixtures at elevated temperatures on oxygen toxicity in mice.
    • To compare the toxic effects of He-O2 at different temperatures and with nitrogen-oxygen (N2-O2) mixtures.

    Main Methods:

    • Mice were exposed for 3 days to a 20%-80% He-O2 environment at 28-30°C.
    • Control groups were exposed to similar N2-O2 and He-O2 atmospheres at room temperature.
    • Physiological parameters including gas exchange, pulmonary inflammation, and survival rates were monitored.

    Main Results:

    • Exposure to He-O2 at 28-30°C resulted in a more rapid decline in gas exchange.
    • Pulmonary inflammatory changes developed faster in the elevated temperature He-O2 group.
    • Animals exposed to He-O2 at warmer temperatures exhibited earlier mortality compared to controls.

    Conclusions:

    • Elevated ambient temperature exacerbates oxygen toxicity when using helium-oxygen mixtures.
    • The type of inert gas (helium vs. nitrogen) may play a role in modulating oxygen toxicity under specific environmental conditions.

    Related Experiment Videos