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Incompatibility of R plasmids from clinical material
Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
|December 1, 1979
Summary
This study characterized thirteen R plasmids from clinical Enterobacteriaceae. The plasmids showed significant diversity in incompatibility groups and traits, despite their shared origin from a limited geographic area.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- R plasmids, or resistance plasmids, are crucial in the dissemination of antimicrobial resistance.
- Enterobacteriaceae are common causes of clinical infections and can harbor R plasmids.
Purpose of the Study:
- To characterize R plasmids isolated from clinical strains of Enterobacteriaceae.
- To investigate the diversity of these plasmids in terms of incompatibility groups and phenotypic characteristics.
Main Methods:
- Isolation of R plasmids from clinical Enterobacteriaceae strains.
- Characterization of plasmids based on incompatibility grouping.
- Assessment of various phenotypic characteristics of the R plasmids.
Main Results:
- Thirteen R plasmids were successfully isolated and characterized.
- The plasmids belonged to multiple incompatibility groups, indicating genetic heterogeneity.
- Significant differences in phenotypic characteristics were observed among the plasmids.
Conclusions:
- R plasmids from clinical Enterobacteriaceae exhibit substantial diversity.
- This diversity exists even among plasmids originating from a confined geographic region.
- Understanding plasmid diversity is essential for tracking and controlling antimicrobial resistance spread.