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Incompatibility of R plasmids from clinical material

C Monti-Bragadin, M Cinco, N Babudri

    Zentralblatt Fur Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie Und Parasitologie
    |December 1, 1979
    PubMed

    Insights

    This study characterized thirteen R plasmids from clinical Enterobacteriaceae. The plasmids showed significant diversity in incompatibility groups and traits, despite their shared origin from a limited geographic area.

    Area of Science:

    • Microbiology
    • Molecular Biology
    • Genetics

    Background:

    • R plasmids, or resistance plasmids, are crucial in the dissemination of antimicrobial resistance.
    • Enterobacteriaceae are common causes of clinical infections and can harbor R plasmids.

    Purpose of the Study:

    • To characterize R plasmids isolated from clinical strains of Enterobacteriaceae.
    • To investigate the diversity of these plasmids in terms of incompatibility groups and phenotypic characteristics.

    Main Methods:

    • Isolation of R plasmids from clinical Enterobacteriaceae strains.
    • Characterization of plasmids based on incompatibility grouping.
    • Assessment of various phenotypic characteristics of the R plasmids.

    Main Results:

    • Thirteen R plasmids were successfully isolated and characterized.
    • The plasmids belonged to multiple incompatibility groups, indicating genetic heterogeneity.
    • Significant differences in phenotypic characteristics were observed among the plasmids.

    Conclusions:

    • R plasmids from clinical Enterobacteriaceae exhibit substantial diversity.
    • This diversity exists even among plasmids originating from a confined geographic region.
    • Understanding plasmid diversity is essential for tracking and controlling antimicrobial resistance spread.

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