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Summary
Relapsing polychondritis (RP) is a rare condition. This study modified diagnostic criteria and found steroids and Dapsone effective in managing RP symptoms and preventing recurrences.
Area of Science:
- Rheumatology
- Immunology
- Rare Diseases
Background:
- Relapsing polychondritis (RP) is a rare multisystemic inflammatory disease of unknown cause.
- Fewer than 211 cases have been reported globally.
- This study presents ten cases from the Cleveland Clinic Foundation.
Purpose of the Study:
- To review and modify diagnostic criteria for Relapsing Polychondritis.
- To evaluate the efficacy of steroids and Dapsone in managing RP.
- To identify common clinical manifestations of RP.
Main Methods:
- Modified McAdam's diagnostic criteria for RP were applied.
- Patients were treated with steroids and/or Dapsone.
- Clinical outcomes including disease activity and recurrence rates were assessed.
Main Results:
- The most common signs included chondritis of the auricles (90%) and arthropathy (80%).
- Other affected areas were the nose (60%), upper respiratory tract (40%), cochlear/vestibular systems (50%), and eyes (50%).
- Steroids and Dapsone effectively reduced disease activity and recurrences.
Conclusions:
- Modified diagnostic criteria enhance RP diagnosis.
- Steroids and Dapsone are reliable treatments for managing RP.
- Dapsone is a viable alternative treatment option for Relapsing Polychondritis.