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Related Experiment Videos

The interaction between ethanol and antihistamines: 2. Clemastine.

H M Franks, V R Hensley, W J Hensley

    The Medical Journal of Australia
    |March 10, 1979
    PubMed
    Summary

    This study found that clemastine, a common antihistamine, did not impair cognitive or motor functions when taken alone. Furthermore, it did not worsen the effects of alcohol on these functions.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Performance

    Background:

    • Antihistamines like clemastine can cause drowsiness.
    • Ethanol (alcohol) is known to impair cognitive and motor functions.

    Purpose of the Study:

    • To investigate the effects of clemastine on perceptual, cognitive, and motor functions.
    • To determine if clemastine potentiates the effects of ethanol on these functions.

    Main Methods:

    • Eighty student volunteers received either clemastine (1 mg), ethanol (0.54 g/kg), or both.
    • Performance was assessed across perceptual, cognitive, and motor tasks.

    Main Results:

    • Clemastine alone did not significantly alter performance in any tested domain.

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  • Clemastine did not exacerbate the performance deficits induced by ethanol.

    • Conclusions:

    • Therapeutic doses of clemastine do not appear to impair key human functions.
    • Clemastine does not enhance the negative cognitive and motor effects of social ethanol consumption.