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Recurrent intracerebral blastomycotic granuloma: diagnosis and treatment
Abstract:
We present a patient with a recurrent intracerebral blastomycotic granuloma. The computerized tomographic scan appearance of this lesion is illustrated. Of the 81 reported cases of intracranial blastomycosis, only 35 have represented solid intracerebral lesions; the other patients have had spinal lesions or meningitis. This patient represents the first reported recurrence of an intracerebral blastomycotic granuloma. The treatment utilized, surgical resection combined with intravenous and intraventricular amphotericin B, represents a unique approach to this problem. The diagnosis and currently advocated treatment of intracranial blastomycosis is reviewed, particularly in regard to the potential for recurrence of blastomycosis.
Insights
This study details the first reported recurrence of an intracerebral blastomycotic granuloma. Treatment involved surgery and amphotericin B, highlighting a unique approach for this rare fungal infection.
Area of Science:
- Mycology
- Neurology
- Infectious Diseases
Background:
- Intracranial blastomycosis is a rare but serious fungal infection.
- Solid intracerebral lesions are less common than meningitis or spinal involvement.
- Recurrence of blastomycotic granulomas presents unique clinical challenges.